From blazes and blizzards to floods and fires, the Missouri and Arkansas Region fulfills the American Red Cross mission to prevent and alleviate human suffering in the face of emergencies. For more than 100 years, the American Red Cross has provided comfort, care, and necessities to those affected by a disasters in Missouri . On the scene following home fires, tornadoes, floods, and power outages, the Missouri and Arkansas Region also responds to an average of twelve house fires every day. We provide immediate assistance for food, shelter, clothing and emotional support.

In addition to disaster relief, the American Red Cross educates the community in emergency preparedness, lifesaving First Aid/CPR/AED and water safety. We also help save lives by educating children and families about home fire safety and installing free smoke alarms in at-risk homes. Mandated by Congress to support communications between military members in the field and their families at home, the Red Cross also assists military families in times of financial crisis​.