The Rotary Club of Kirksville is a local club associated with Rotary International. The club held its first regular meeting at noon on Wednesday, January 2, 1918, in the dining room of the Pool Hotel.  Its charter was presented on Wednesday, March 17, 1918, becoming the sixth club in the state of Missouri and No. 371 of Rotary International.

In the 90 plus years since its founding, the Rotary Club of Kirksville has been an important part of the Kirksville community as well as the greater Rotary International community.