The Saline County Chamber of Commerce was established in 2003, when the Harrisburg and Eldorado Chambers merged. They invited Carrier Mills, Stonefort, Galatia, Raleigh, and Muddy to join them in promoting business in the Saline County area. Thus the Saline County Chamber of Commerce was born.

Since it's inception, the Chamber has focused on increasing business awareness and recognition for businesses within the county. It conducts various events throughout the year giving members the opportunity for networking and business promotion. It also provides a forum for Chamber members to discuss events and issues that impact local businesses.

Named for Saline Creek, which was named for the salt springs in the area, Saline County has a population of almost 27,000 residents and is made up of seven municipalities: the cities of Eldorado and Harrisburg and the villages of Carrier Mills, Galatia, Muddy, Raleigh and Stonefort.